In clinical trials with Bupropion HCl immediate-release, 10% of patients and volunteers discontinued due to an adverse reaction. Reactions resulting in discontinuation in addition to those listed above for the sustained-release formulation included vomiting, seizures, and sleep disturbances. Hilliard WT, Barloon L, Farley P, Penn JV, Koranek A July 2013. "Bupropion diversion and misuse in the correctional facility". J Correct Health Care. There have been a number of anecdotal and case-study reports of bupropion abuse, but the bulk of evidence indicates that the subjective effects of bupropion via the oral route are markedly different from those of addictive stimulants such as cocaine or amphetamine.
BuPROPion. Specifically, seizure threshold may be lowered. Urogenital: Frequent was urinary frequency. Vortioxetine. BuPROPion may increase the serum concentration of Vortioxetine. Management: The vortioxetine dose should be reduced by 50% when used together with bupropion. Following cessation of bupropion, the vortioxetine dose should be returned to the normal level. Hyperglycemia, hypoglycemia, and syndrome of inappropriate antidiuretic hormone secretion. Do not change your dose or stop taking Bupropion hydrochloride extended-release tablets XL without talking with your healthcare provider first.
The expected result is the increase of bupropion and decrease of hydroxybupropion blood concentration. Animal data indicated that Bupropion may be an inducer of drug-metabolizing enzymes in humans. In a study of 8 healthy male volunteers, following a 14-day administration of Bupropion 100 mg three times per day, there was no evidence of induction of its own metabolism. Nevertheless, there may be the potential for clinically important alterations of blood levels of coadministered drugs. Does Taking Stimulants for ADHD Lead to Substance Abuse Problems? FLUoxetine. BuPROPion may increase the serum concentration of FLUoxetine.
Research Findings. 20 5. And I have a severe headache, my sinuses and throat are burning so bad it's almost unbearable! National Birth Defects Prevention Study NBDPS did not show an increased risk for cardiovascular malformations overall after Bupropion exposure during the first trimester.
SA, Montejo AL, Detke MJ. Duloxetine in the prevention of relapse of major depressive disorder: double-blind placebo-controlled study. Br J Psychiatry. Teva version of 300 mg bupropion hydrochloride. FDA does not currently have data indicating that the other four generic products are not bioequivalent to Wellbutrin XL 300 mg. The Agency will review the data from the additional bioequivalence studies when the data are received, and will provide additional updates at that time. The figure below illustrates the concentration-time curves for the two formulations. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. May be taken without regard to meals. The manufacturer states that tablets should be swallowed whole; do not crush, chew, or divide. What should I discuss with my healthcare provider before taking Wellbutrin SR bupropion? Alcohol causes an increase of CYP2B6 in the liver, and persons with a history of alcohol use metabolize bupropion faster. The pooled analyses of placebo-controlled trials in children and adolescents with MDD, obsessive compulsive disorder OCD or other psychiatric disorders included a total of 24 short-term trials of 9 antidepressant drugs in over 4400 patients. What are the ingredients in Bupropion hydrochloride extended-release tablets, USP XL? The recommended starting dose for SAD is 150 mg once daily. After 7 days of dosing, the dose may be increased to the target dose of 300 mg once daily in the morning. Doses above 300 mg of Bupropion HCl extended-release were not assessed in the SAD trials. How should I take Wellbutrin SR bupropion?
Forfivo XL is not recommended in patients with renal impairment. Advise patients to notify their healthcare provider if they become pregnant or intend to become pregnant during therapy. In many of these cases, a causal relationship to Bupropion treatment is not certain, because depressed mood can be a symptom of nicotine withdrawal. However, some of the cases occurred in patients taking Bupropion who continued to smoke. Accommodation abnormality, dry eye, deafness, increased intraocular pressure, angle-closure glaucoma, and mydriasis. DON'T PLAY WITH THIS DRUG! cycrin
Wellbutrin bupropion hydrochloride US prescribing information. Forfivo XL: Because the 450 mg tablet is the only available dose formulation, use another bupropion formulation for tapering the dose prior to discontinuation. There have been reports of people using ADHD stimulants that weren't prescribed for them. People have crushed and snorted Ritalin tablets or dissolved the drug in water and taken it intravenously. Studies show that abusing Ritalin can lead to dependence on the drug. When carefully taken as prescribed, though, Ritalin is less likely to be addictive in children or adults. Just don't fucking do it. If you are that desperate for a high then you need to take a step back a think about how you got to the point where you are about to abuse an NDRI that is anything but recreational. If you are resorting to getting high from this substance then it is probably time to seek out some counseling or some sort of therapeutic intervention. If you can get any other drugs then abuse them. But when you have reached a point in your life where, after now knowing the risks, you feel abusing this drug is a worthwhile venture then it is time to get help or a serious reality check. What is the regulatory history of Wellbutrin and generic bupropion? WELLBUTRIN bupropion hydrochloride an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines. odlot.info eulexin
In order to evaluate this series of post-marketing reports, we have re-examined both the data on the bioequivalence of the two products Wellbutrin XL and Teva's bupropion XL and what is known about the natural history of treated depression. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Too much of this medicine can increase your risk of a seizure. Ajmaline: CYP2D6 Inhibitors Moderate may increase the serum concentration of Ajmaline. Sometimes it takes trying a few things to find the right one. Ticlopidine and Clopidogrel: Concomitant treatment with these drugs can increase Bupropion exposures but decrease hydroxyBupropion exposure. Damaj MI, Carroll FI, Eaton JB, et al. September 2004. "Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors". Mol. Pharmacol. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. generic bactrim purchase shop australia
Bupropion, including ZYBAN used to help people stop smoking APLENZIN, FORFIVO XL, WELLBUTRIN or WELLBUTRIN SR. Bupropion is the same active ingredient that is in Bupropion hydrochloride extended-release tablets XL. ADDERALL XR amphetamine, dextroamphetamine mixed salts is a once daily extended-release, single-entity amphetamine product. The question of whether or not such lesions may be precursors of neoplasms of the liver is currently unresolved. Similar liver lesions were not seen in the mouse study, and no increase in malignant tumors of the liver and other organs was seen in either study. Trials 1, 2 and 3, respectively. Taylor D, Carol P, Shitij K 2012. The Maudsley prescribing guidelines in psychiatry. West Sussex: Wiley-Blackwell.
Adderall XR utilizes the Microtrol extended-release delivery system, incorporating two types of beads. The first dissolves immediately, releasing half of the medication, while the second type dissolves much more slowly, releasing the remaining medication four hours later. Maximum plasma concentration is achieved in seven hours, compared to instant-release Adderall, which reaches maximum plasma concentration within three hours. Elderly: Use with caution in the elderly; may be at greater risk of drug accumulation during chronic dosing. Consider a reduction in dose. Ioflupane I 123: BuPROPion may diminish the diagnostic effect of Ioflupane I 123. MPORTANT: Be sure to read the three sections of this Medication Guide. The first section is about the risk of suicidal thoughts and actions with antidepressant medicines; the second section is about the risk of changes in thinking and behavior, depression and suicidal thoughts or actions with medicines used to quit smoking; and the third section is entitled “What Other Important Information Should I Know About Bupropion Hydrochloride Extended-Release Tablets XL? CYP2D6 such as Bupropion. Bupropion comes as a tablet and a sustained-release or extended-release long-acting tablet to take by mouth. The regular tablet Wellbutrin is usually taken three times a day, with doses at least 6 hours apart, or four times a day, with doses at least 4 hours apart. The sustained-release tablet Wellbutrin SR, Zyban is usually taken twice a day, with doses at least 8 hours apart. The extended-release tablet Aplenzin, Wellbutrin XL is usually taken once daily in the morning; doses of the extended-release tablet should be taken at least 24 hours apart. When bupropion is used to treat seasonal affective disorder, it is usually taken once a day in the morning beginning in the early fall, continuing through the winter, and stopping in the early spring. Sometimes a lower dose of bupropion is taken for 2 weeks before the medication is stopped. Take bupropion with food if the medication upsets your stomach. If you have trouble falling asleep or staying asleep, do not take bupropion too close to bedtime. Take bupropion at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take bupropion exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Byrne SE, Rothschild AJ. Loss of antidepressant efficacy during maintenance therapy: possible mechanisms and treatments. J Clin Psychiatry. Drug Metabolism and Disposition. Cognitive impairment: May cause motor or cognitive impairment in some patients, which may impair physical or mental abilities; patients must be cautioned about performing tasks which require mental alertness eg, operating machinery or driving. rabeprazole 100mg uk
Advise the patient to read the FDA-approved patient labeling Medication Guide. ADHD medicines are available. Extended release tablet: Insoluble tablet shell may remain intact and be visible in the stool. Aminoketone antidepressant structurally different from all other marketed antidepressants; like other antidepressants the mechanism of bupropion's activity is not fully understood. Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine, and does not inhibit monoamine oxidase or the reuptake of serotonin. Metabolite inhibits the reuptake of norepinephrine. MAO inhibitor recommendations: Refer to adult dosing. Read the Guide provided by your before you start using and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Bupropion hydrochloride extended-release tablets XL if you stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider. After smoking for 30 years, my doctor gave me a Zyban kit. I started taking the Zyban - one a day for the first three days, then 2 a day after that. If upset occurs, take with food. Compare prices and print coupons for Bupropion XL Wellbutrin XL and other Depression drugs at CVS, Walgreens, and other pharmacies. Make plans for both the near future and further down the road. sucralfate online low price
Li Z, Maglione M, Tu W, Mojica W, Arterburn D, Shugarman LR, Hilton L, Suttorp M, Solomon V, Shekelle PG, Morton SC April 2005. "Meta-analysis: pharmacologic treatment of obesity". Ann. Intern. Med. Today Msnbc. Retrieved 2009-06-23. This drug saved my life, and probably my marriage. I have experienced no side effects whatsoever. I started on 150mg time release two years ago, and after six months increased to 300mg time release. I take it early every morning once per day, but do not find that it has any effect my ability to sleep. MAO Inhibitors: May enhance the hypertensive effect of BuPROPion. The risk of seizures is also related to patient factors, clinical situations, and concomitant medications that lower the seizure threshold. Consider these risks before initiating treatment with Bupropion hydrochloride extended-release tablets XL. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding. Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Yes, you are correct. Bupropion Wellbutrin is not an SSRI and is structurally very different than any typical anti-depressant. It is an aminoketone, as you stated, and resembles a phenythlamine; more specifically, it resembles a cathinone. It does not act on serotonin whatsoever and is a unique drug due to its action as an NDRI and a nicotinic antagonist. The latter is why it is prescribed for smoking cessation. Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. College campuses known to be highly competitive or have a high rate of binge drinking had up to 25% of students use an ADHD medication within one year, a survey of students at 119 colleges across the country concluded. In a study comparing 14-day dosing with Bupropion hydrochloride extended-release tablets XL 300 mg once-daily to the immediate-release formulation of Bupropion at 100 mg 3 times daily, equivalence was demonstrated for peak plasma concentration and area under the curve for Bupropion and the three metabolites hydroxyBupropion, threohydroBupropion, and erythrohydroBupropion. As a result of the large clinical trial review, FDA is removing the Boxed Warning, FDA's most prominent warning, for serious mental health side effects from the varenicline drug label. The language describing the serious mental health side effects seen in patients quitting smoking will also be removed from the Boxed Warning in the bupropion label. FDA is also updating the existing warning section in both labels that describes the side effects on mood, behavior, or thinking to include the results from the clinical trial. This decision is consistent with the recommendations of external experts at a September 2016 FDA Advisory Committee meeting. The patient Medication Guide that explains the risks associated with the use of the medicines will continue to be provided with every patient prescription; however, the risk evaluation and mitigation strategy REMS that formally required the Medication Guide will be removed. It enables the user to focus and stay awake. Stories of students writing papers continuously for an unusually long time or “cramming” all night for an exam with no loss of energy or concentration are common. Bupropion may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. For this analysis the FDA combined the results of 295 trials of 11 antidepressants in order to obtain statistically significant results. Considered in isolation, bupropion was not statistically different from placebo. astonin
Bupropion hydrochloride extended-release tablets XL can cause seizure. The risk of seizure is dose-related. The dose should not exceed 300 mg once daily. Increase the dose gradually. Discontinue Bupropion hydrochloride extended-release tablets XL and do not restart treatment if the patient experiences a seizure. Tyndale, R. F. 3 September 2014. AUC of Bupropion by 40% and 60% for clopidogrel, by 38% and 85% for ticlopidine, respectively. The exposures of hydroxyBupropion were decreased. People with ADHD tend to be more impulsive and likely to have behavior problems, both of which can contribute to drug and alcohol abuse, researchers say. Also, both ADHD and tend to run in families. A child with ADHD who has a parent with alcoholism is more likely to also develop an alcohol abuse problem. Researchers have pointed to common genes shared between ADHD and alcoholism. Check your pressure regularly and tell your doctor if the results are high. MAOI within 2 weeks of stopping Bupropion hydrochloride extended-release tablets XL unless directed to do so by your healthcare provider. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Codeine: CYP2D6 Inhibitors Moderate may diminish the therapeutic effect of Codeine. These CYP2D6 inhibitors may prevent the metabolic conversion of codeine to its active metabolite morphine. Some people have severe allergic reactions to Bupropion hydrochloride extended-release tablets XL. Stop taking Bupropion hydrochloride extended-release tablets XL and call your healthcare provider right away if you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, chest pain, or have trouble breathing. These could be signs of a serious allergic reaction. OK to have one cookie every now and then. Bupropion and its metabolites are cleared renally and may accumulate in such patients to a greater extent than usual. If you have or think you might, you can learn how to form a positive -- and that can help you stop overeating. Bupropion is extensively metabolized in humans. Three metabolites are active: hydroxyBupropion, which is formed via hydroxylation of the tert-butyl group of Bupropion, and the amino-alcohol isomers threohydroBupropion and erythrohydroBupropion, which are formed via reduction of the carbonyl group. In vitro findings suggest that CYP2B6 is the principal isoenzyme involved in the formation of hydroxyBupropion, while cytochrome P450 enzymes are not involved in the formation of threohydroBupropion. Oxidation of the Bupropion side chain results in the formation of a glycine conjugate of meta-chlorobenzoic acid, which is then excreted as the major urinary metabolite. The potency and toxicity of the metabolites relative to Bupropion have not been fully characterized. However, it has been demonstrated in an antidepressant screening test in mice that hydroxyBupropion is one half as potent as Bupropion, while threohydroBupropion and erythrohydroBupropion are 5-fold less potent than Bupropion. This may be of clinical importance, because the plasma concentrations of the metabolites are as high or higher than those of Bupropion. This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. But trying to cut calories or not eating certain kinds of foods can trigger overeating, and that can make it harder for you to recover from the disorder. Consult full interaction monograph for specific recommendations.
Hypertension: May elevate blood pressure and cause hypertension. Events have been observed in patients with or without evidence of preexisting hypertension. The risk is increased when used concomitantly with monoamine oxidase inhibitors, nicotine replacement, or other drugs that increase dopaminergic or noradrenergic activity. Assess blood pressure before treatment and monitor periodically. However, you might want to avoid people who make negative comments about your eating or your weight. Buck, ML March 2002. The efficacy of the immediate-release formulation of Bupropion was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult patients with MDD. Although bupropion is not approved for smoking cessation except for Buproban and Zyban observe all patients for neuropsychiatric reactions. Instruct the patient to contact a healthcare provider if such reactions occur. Efficacy of maintenance therapy 300 mg daily has been demonstrated for up to 6 months. Conversely, if significant progress has not been made by the seventh week of therapy, success is unlikely and treatment discontinuation should be considered. Your doctor may prescribe nicotine patches or gum to help you stop smoking. Do not smoke at any time if you are using a nicotine product along with Zyban. Too much nicotine can cause serious side effects. Shire retains exclusive patent rights until the patent expires, expected in 2018. So statistically, there is a marked increase in seizure risk from taking bupropion as prescribed. By bypassing first-pass metabolism this seizure risk increases exponentially. Someone, like yourself, who is bypassing first-pass metabolism by taking the drug intravenously would have a exponentially higher risk of experiencing a seizure compared to the already exponentially higher risk to someone who is bypassing first-pass metabolism by insufflating the bupropion. If you miss a dose, do not take an extra tablet to make up for the dose you missed. Wait and take your next tablet at the regular time. This is very important. Too many Bupropion hydrochloride extended-release tablets XL can increase your chance of having a seizure. Why Are People With ADHD More Likely to Abuse Drugs and Alcohol? Serious neuropsychiatric reactions have occurred in patients taking bupropion for smoking cessation. The majority of these reactions occurred during bupropion treatment, but some occurred in the context of discontinuing treatment. In many cases, a causal relationship to bupropion treatment is not certain, because depressed mood may be a symptom of nicotine withdrawal. However, some of the cases occurred in patients taking bupropion who continued to smoke. to order condylox
FDA has approved five generic versions of Wellbutrin XL 300 mg. Each of these generics was approved based on bioequivalence studies comparing the 150 mg strength of the products to Wellbutrin XL 150 mg. Studies were not performed directly on the 300 mg strength of the products. Rather, the bioequivalence studies were performed using the 150 mg strength, and the results were extrapolated to establish bioequivalence of the 300 mg product. Cantwell DP 1998. "ADHD through the life span: the role of bupropion in treatment". J Clin Psychiatry. Cipriani A, Furukawa TA, Salanti G, Geddes JR, Higgins JP, Churchill R, Watanabe N, Nakagawa A, Omori IM, McGuire H, Tansella M, Barbui C February 2009. PDF. Lancet. AUC at steady state is about 13 times that of Bupropion. The times to peak concentrations for the erythrohydroBupropion and threohydroBupropion metabolites are similar to that of hydroxyBupropion. Bupropion and its active metabolites was 2% of the maternal weight-adjusted dose. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. However, there is substantial evidence from placebo-controlled maintenance trials in adults with depression that the use of antidepressants can delay the recurrence of depression. Eliglustat: CYP2D6 Inhibitors Moderate may increase the serum concentration of Eliglustat. Management: Reduce the eliglustat dose to 84 mg daily. Avoid use of eliglustat in combination with a moderate CYP2D6 inhibitor and a strong or moderate CYP3A4 inhibitor. Bupropion is a primarily used as an and aid. It is marketed as Wellbutrin and Zyban among other trade names. Bupropion. In addition, pooled analysis of Bupropion pharmacokinetic data from 90 healthy male and 90 healthy female volunteers revealed no sex-related differences in the peak plasma concentrations of Bupropion. The mean systemic exposure AUC was approximately 13% higher in male volunteers compared to female volunteers. Wellbutrin has become a hobby of mine. Back when I was on crack, heroin, coke, ice, crank, pills, morphine, and anything else that I could get into the syringe, I loved the process of getting high. Spoons, lighters, pipes, rigs, char-boy, glass roses, etc. cheapest place trazodone
This mechanism creates the potential for a variety of drug interactions. Kampman KM June 2008. First drug for seasonal depression". FDA Consum. 40 5: 7. 2006. Allow 14 days to elapse between discontinuing bupropion and initiation of an MAO inhibitor intended to treat depression. Nevada State Athletic Commission has also banned athletes in the state from using Adderall. Tim Credeur was removed from a UFC fight on the finale of The Ultimate Fighter 7 because of a positive drug test due to his use of it. In the National Football League, New Orleans Saints kicker Garrett Hartley served a four-game suspension when the 2009 NFL regular season began because he tested positive for the banned stimulant. The Arizona Cardinals tight end Ben Patrick received a four-game suspension as a result of using Adderall. Retrieved 27 May 2013. Adderall has been shown to significantly reduce symptoms associated with attention-deficit hyperactivity disorder ADHD and in many patients it presents minimal side-effects. Depending on dosage, the beneficial effects of stimulant medications can last several hours, allowing improved performance throughout the day. Both bupropion and amphetamine have noradrenergic and dopaminergic activity. Dipyrone: May decrease the serum concentration of BuPROPion. PDF. United States Food and Drug Administration. 10 September 2014. FDA has not identified any new safety information associated with Budeprion XL 300 mg; however, in some patients, the drug may not provide the desired efficacy beneficial effect. alendronate
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It is not known exactly how bupropion works to reduce urges. In the SAD trials, 82% of patients were treated with 300 mg per day, and 18% were treated with 150 mg per day. The mean daily dose was 270 mg per day. The mean duration of Bupropion exposure was 126 days. Aplenzin: In patients receiving 348 mg once daily, taper dose down to 174 mg once daily for 2 weeks prior to discontinuing.
JT Cody, S Valtier, SL Nelson. Amphetamine excretion profile following multidose administration of mixed salt amphetamine preparation. J. Anal. Toxicol. Taylor D December 2008. "Antidepressant drugs and cardiovascular pathology: a clinical overview of effectiveness and safety". Acta Psychiatr Scand. Your doctor may need to monitor your pressure closely. Do not smoke at any time if using any nicotine products with this drug. Too much nicotine can cause serious side effects.
Bupropion has pro-convulsant properties that may be enhanced or cumulatively potentiated by amphetamine. Bupropion hydrochloride extended-release, an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines. Bupropion is an aminoketone, essentially a substituted amphetamine, and is related to the diet drug diethylpropion. In the US, diethylpropion is a schedule IV drug, so it clearly has abuse potential. I just feel that bupropion has JUST ENOUGH effect on dopamine to feel good to some people. I am predisposed to addiction. I feel ashamed honestly that I insufflate bupropion because it is extremely looked down upon on the internet. I would be extremely embarrassed if someone found out I was sniffing Wellbutrin.
Nilotinib: May decrease the serum concentration of CYP2B6 Substrates. Nobles, Sylvia Tindell 2001. It is a brand-name psychostimulant medication composed of racemic amphetamine aspartate monohydrate, racemic amphetamine sulfate, dextroamphetamine saccharide, and dextroamphetamine sulfate, which are all amphetamine salts. It is thought to work by increasing the amount of dopamine and norepinephrine in the brain. In addition, the drug also acts as a potent dopamine reuptake inhibitor and norepinephrine reuptake inhibitor. It is sold under many trade names worldwide including Aplenzin, Budeprion SR, Bup, Bupredol, Buproban, Bupropion GSK, BuPROPion HCL SR Watson, Bupropion Hydrochloride Anchen, Bupropion Hydrochloride Apotex, BuPROPion Hydrochloride Cadista, Bupropion Hydrochloride Mylan, Bupropion Hydrochloride Sandoz, buPROPion Hydrochloride SR actavis, Bupropion Hydrochloride Sun Pharma, buPROPion Hydrochloride Torrent Pharma, Bupropion Hydrochloride Wockhardt, buPROPion Hydrochloride XL actavis, BuPROPion Hydrochloride XL Watson, Bupropion SR Sanis Health, Bupropionhydrochlorid HEXAL, Bupropionhydrochloride GSK, Buprotrin, Butrin, Buxon, Carmubine, Depnox-SR, Elontril, Elontril XL, Forfivo XL, Funnix, Global buPROPion HCL, Le Fu Ting, Odranal, PMS-Bupropion SR, Prewell, Quomem, ratio-Bupropion SR, Sandoz Bupropion SR, Voxra, Wellbutrin, Wellbutrin Retard, Wellbutrin SR, Wellbutrin XL, Wellbutrin XR, Yue Ting, Zetron, Zyban, Zyban LP, Zybex SR, ZyGenerics Bupropion Hydrochloride XL, and Zyntabac.